Homo sapiens Protein: AJUBA
InnateDB Protein IDBP-2968.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AJUBA
Protein Name jub, ajuba homolog (Xenopus laevis)
Species Homo sapiens
Ensembl Protein ENSP00000262713
InnateDB Gene IDBG-2966 (AJUBA)
Protein Structure
UniProt Annotation
Function Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell- cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1- induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. {ECO:0000269PubMed:12417594, ECO:0000269PubMed:13678582, ECO:0000269PubMed:15870274, ECO:0000269PubMed:16413547, ECO:0000269PubMed:17909014, ECO:0000269PubMed:18805794, ECO:0000269PubMed:20303269, ECO:0000269PubMed:20616046, ECO:0000269PubMed:22286099}.
Subcellular Localization Cytoplasm, cytoskeleton. Cell membrane. Cell junction. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, P-body. Note=Shuttles between the cytoplasm and the nucleus. Localizes on centrosomes during G2-M phase. Preferentially co- localizes with cadherin-adhesive complexes at sites of cell-cell contacts. Colocalizes with GFI1 in the nucleus.
Disease Associations
Tissue Specificity
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 33 [view]
Protein-DNA 1 [view]
Protein-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0045294 alpha-catenin binding
GO:0051015 actin filament binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000278 mitotic cell cycle
GO:0001666 response to hypoxia
GO:0006351 transcription, DNA-templated
GO:0016339 calcium-dependent cell-cell adhesion
GO:0030032 lamellipodium assembly
GO:0030334 regulation of cell migration
GO:0031328 positive regulation of cellular biosynthetic process
GO:0031334 positive regulation of protein complex assembly
GO:0033673 negative regulation of kinase activity
GO:0033674 positive regulation of kinase activity
GO:0034613 cellular protein localization
GO:0035195 gene silencing by miRNA
GO:0035313 wound healing, spreading of epidermal cells
GO:0035331 negative regulation of hippo signaling
GO:0043087 regulation of GTPase activity
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043406 positive regulation of MAP kinase activity
GO:0046474 glycerophospholipid biosynthetic process
GO:0048041 focal adhesion assembly
GO:1900037 regulation of cellular response to hypoxia
GO:2000637 positive regulation of gene silencing by miRNA
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0030027 lamellipodium
Protein Structure and Domains
InterPro IPR001781 Zinc finger, LIM-type
PFAM PF00412
Post-translational Modifications
SwissProt Q96IF1
PhosphoSite PhosphoSite-Q96IF1
UniProt Splice Variant
Entrez Gene 84962
UniGene Hs.655832
RefSeq NP_116265
OMIM 609066
HPRD 16426
EMBL AK096128 AL132780 AY169959 BC007580 BC034968 CH471078
GenPept AAH07580 AAH34968 AAO37641 BAG53217 EAW66204 EAW66205