InnateDB Protein
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IDBP-2968.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AJUBA
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Protein Name
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jub, ajuba homolog (Xenopus laevis)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000262713
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InnateDB Gene
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IDBG-2966 (AJUBA)
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Protein Structure
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Function |
Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell- cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1- induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. {ECO:0000269PubMed:12417594, ECO:0000269PubMed:13678582, ECO:0000269PubMed:15870274, ECO:0000269PubMed:16413547, ECO:0000269PubMed:17909014, ECO:0000269PubMed:18805794, ECO:0000269PubMed:20303269, ECO:0000269PubMed:20616046, ECO:0000269PubMed:22286099}.
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Subcellular Localization |
Cytoplasm, cytoskeleton. Cell membrane. Cell junction. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, P-body. Note=Shuttles between the cytoplasm and the nucleus. Localizes on centrosomes during G2-M phase. Preferentially co- localizes with cadherin-adhesive complexes at sites of cell-cell contacts. Colocalizes with GFI1 in the nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
34
[view]
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Protein-Protein |
33
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001781
Zinc finger, LIM-type
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PFAM |
PF00412
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PRINTS |
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PIRSF |
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SMART |
SM00132
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TIGRFAMs |
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Modification |
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SwissProt |
Q96IF1
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PhosphoSite |
PhosphoSite-Q96IF1
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TrEMBL |
G3V5F5
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UniProt Splice Variant |
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Entrez Gene |
84962
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UniGene |
Hs.655832
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RefSeq |
NP_116265
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HUGO |
HGNC:20250
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OMIM |
609066
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CCDS |
CCDS9581
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HPRD |
16426
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IMGT |
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EMBL |
AK096128
AL132780
AY169959
BC007580
BC034968
CH471078
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GenPept |
AAH07580
AAH34968
AAO37641
BAG53217
EAW66204
EAW66205
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