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InnateDB Protein
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IDBP-29823.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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USP43
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Protein Name
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ubiquitin specific peptidase 43
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000285199
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InnateDB Gene
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IDBG-29819 (USP43)
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Protein Structure
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| Function |
May recognize and hydrolyze the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly- ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). {ECO:0000250}.
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| Subcellular Localization |
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| Disease Associations |
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| Tissue Specificity |
Expressed in brain, aorta and lung at low levels. {ECO:0000269PubMed:14715245}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
| Experimentally validated |
| Total |
10
[view]
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| Protein-Protein |
10
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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Molecular Function |
| Accession |
GO Term |
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GO:0008234
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cysteine-type peptidase activity
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GO:0036459
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ubiquitinyl hydrolase activity
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| Biological Process |
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GO:0006511
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ubiquitin-dependent protein catabolic process
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR001394
Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR028889
Ubiquitin carboxyl-terminal hydrolase-like domain
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| PFAM |
PF00443
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q70EL4
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| PhosphoSite |
PhosphoSite-Q70EL4
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
124739
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| UniGene |
Hs.709621
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| RefSeq |
NP_694942
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| HUGO |
HGNC:20072
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| OMIM |
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| CCDS |
CCDS45610
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| HPRD |
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| IMGT |
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| EMBL |
AC027045
AC118755
AJ583817
AK055188
AK090821
BC136368
BC144041
BC171759
CH471108
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| GenPept |
AAI36369
AAI44042
AAI71759
BAB70869
CAE47744
EAW90022
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Version 5.4