Version 5.4
Homo sapiens Protein: HRSP12
Summary
InnateDB Protein IDBP-29884.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HRSP12
Protein Name heat-responsive protein 12
Synonyms P14.5; PSP; UK114;
Species Homo sapiens
Ensembl Protein ENSP00000254878
InnateDB Gene IDBG-29882 (HRSP12)
Protein Structure
UniProt Annotation
Function Endoribonuclease responsible for the inhibition of the translation by cleaving mRNA. Inhibits cell-free protein synthesis. Cleaves phosphodiester bonds only in single-stranded RNA (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm. Nucleus. Note=Mostly cytoplasmic but, in less differentiated cells occasionally nuclear.
Disease Associations
Tissue Specificity Hepatocytes and renal distal tubular epithelial cells. Only weak expression in other tissues.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 19 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004519 endonuclease activity
GO:0019239 deaminase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006449 regulation of translational termination
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR006056 Enamine/imine deaminase YjgF-like
IPR006175 YjgF/Yer057p/UK114 family
IPR013813 Endoribonuclease L-PSP/chorismate mutase-like
PFAM PF01042
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P52758
PhosphoSite PhosphoSite-P52758
TrEMBL A0A024R9H2
UniProt Splice Variant
Entrez Gene 10247
UniGene Hs.597599
RefSeq NP_005827
HUGO HGNC:16897
OMIM 602487
CCDS CCDS6276
HPRD 03924
IMGT
EMBL AY026764 BC010280 BC012592 BC093059 CH471060 CR456844 CR541652 X95384
GenPept AAH10280 AAH12592 AAH93059 AAK01939 CAA64670 CAG33125 CAG46453 EAW91774 EAW91775

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca