InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SYT9

Summary

InnateDB Protein

IDBP-30060.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SYT9

Protein Name

synaptotagmin IX

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000324419

InnateDB Gene

IDBG-30058 (SYT9)

Protein Structure

UniProt Annotation

Function

May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006810	transport
GO:0017158	regulation of calcium ion-dependent exocytosis
GO:0045956	positive regulation of calcium ion-dependent exocytosis
GO:0050796	regulation of insulin secretion

Cellular Component

GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030141	secretory granule
GO:0030667	secretory granule membrane
GO:0030672	synaptic vesicle membrane
GO:0031045	dense core granule