InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCNT1

Summary

InnateDB Protein

IDBP-30256.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCNT1

Protein Name

cyclin T1

Synonyms

CCNT; CYCT1; HIVE1;

Species

Homo sapiens

Ensembl Protein

ENSP00000261900

InnateDB Gene

IDBG-30254 (CCNT1)

Protein Structure

UniProt Annotation

Function

Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269PubMed:16109376, ECO:0000269PubMed:16109377}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12944466}.

Disease Associations

Tissue Specificity

Ubiquitously expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 94 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	94 [view]
Protein-Protein	87 [view]
Protein-DNA	4 [view]
Protein-RNA	1 [view]
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0017069	snRNA binding
GO:0019901	protein kinase binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006351	transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0010467	gene expression
GO:0016032	viral process
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050434	positive regulation of viral transcription
GO:0051301	cell division