InnateDB Protein
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IDBP-30554.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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POLR2K
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Protein Name
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polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
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Synonyms
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ABC10-alpha; hRPB7.0; hsRPB10a; RPABC4; RPB10alpha; RPB12; RPB7.0;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000342889
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InnateDB Gene
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IDBG-30552 (POLR2K)
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Protein Structure
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Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
22
[view]
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Protein-Protein |
16
[view]
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Protein-DNA |
5
[view]
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0000398
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mRNA splicing, via spliceosome
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GO:0006281
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DNA repair
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GO:0006283
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transcription-coupled nucleotide-excision repair
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GO:0006289
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nucleotide-excision repair
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GO:0006351
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transcription, DNA-templated
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GO:0006356
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regulation of transcription from RNA polymerase I promoter
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GO:0006360
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transcription from RNA polymerase I promoter
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GO:0006361
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transcription initiation from RNA polymerase I promoter
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GO:0006362
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transcription elongation from RNA polymerase I promoter
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GO:0006363
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termination of RNA polymerase I transcription
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0006367
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transcription initiation from RNA polymerase II promoter
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GO:0006368
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transcription elongation from RNA polymerase II promoter
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GO:0006370
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7-methylguanosine mRNA capping
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GO:0006383
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transcription from RNA polymerase III promoter
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GO:0006385
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transcription elongation from RNA polymerase III promoter
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GO:0006386
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termination of RNA polymerase III transcription
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GO:0008380
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RNA splicing
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GO:0010467
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gene expression
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GO:0016032
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viral process
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GO:0032481
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positive regulation of type I interferon production
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GO:0045087
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innate immune response
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GO:0050434
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positive regulation of viral transcription
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Cellular Component |
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PDB ID |
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InterPro |
IPR006591
RNA polymerase archaeal subunit P/eukaryotic subunit RPABC4
IPR029040
RNA polymerase subunit RPABC4/transcription elongation factor Spt4
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PFAM |
PF03604
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PRINTS |
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PIRSF |
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SMART |
SM00659
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TIGRFAMs |
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Modification |
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SwissProt |
P53803
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PhosphoSite |
PhosphoSite-
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TrEMBL |
A0A024R9G0
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UniProt Splice Variant |
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Entrez Gene |
5440
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UniGene |
Hs.665638
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RefSeq |
NP_005025
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HUGO |
HGNC:9198
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OMIM |
606033
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CCDS |
CCDS6285
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HPRD |
05826
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IMGT |
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EMBL |
AJ252078
BC000806
BC018157
CH471060
CR456870
Z47727
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GenPept |
AAH00806
AAH18157
CAA87656
CAB91873
CAG33151
EAW91798
EAW91799
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