InnateDB Protein
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IDBP-3075.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TCEB3B
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Protein Name
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transcription elongation factor B polypeptide 3B (elongin A2)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000331302
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InnateDB Gene
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IDBG-3073 (TCEB3B)
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Protein Structure
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Function |
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). {ECO:0000269PubMed:10692460}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Specifically expressed in testis. {ECO:0000269PubMed:10692460}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
16
[view]
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Protein-Protein |
16
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0032784
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regulation of DNA-templated transcription, elongation
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Cellular Component |
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PDB ID |
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InterPro |
IPR003617
Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type
IPR010684
RNA polymerase II transcription factor SIII, subunit A
IPR017923
Transcription factor IIS, N-terminal
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PFAM |
PF06881
PF08711
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PRINTS |
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PIRSF |
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SMART |
SM00509
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TIGRFAMs |
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Modification |
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SwissProt |
Q8IYF1
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PhosphoSite |
PhosphoSite-Q8IYF1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
51224
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UniGene |
Hs.375035
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RefSeq |
NP_057511
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HUGO |
HGNC:30771
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OMIM |
609522
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CCDS |
CCDS11932
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HPRD |
18169
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IMGT |
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EMBL |
AB030834
BC036022
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GenPept |
AAH36022
BAA90665
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