InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PABPC1

Summary

InnateDB Protein

IDBP-30849.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PABPC1

Protein Name

poly(A) binding protein, cytoplasmic 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000313007

InnateDB Gene

IDBG-30847 (PABPC1)

Protein Structure

UniProt Annotation

Function

Binds the poly(A) tail of mRNA, including that of its own transcript. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding- region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. {ECO:0000269PubMed:11051545, ECO:0000269PubMed:17212783, ECO:0000269PubMed:18447585, ECO:0000269PubMed:20573744}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between the cytoplasm and the nucleus.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 242 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	242 [view]
Protein-Protein	235 [view]
Protein-DNA	2 [view]
Protein-RNA	5 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008143	poly(A) binding
GO:0008266	poly(U) RNA binding
GO:0008494	translation activator activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0000398	mRNA splicing, via spliceosome
GO:0006378	mRNA polyadenylation
GO:0006412	translation
GO:0006413	translational initiation
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0031047	gene silencing by RNA
GO:0044267	cellular protein metabolic process
GO:0045727	positive regulation of translation
GO:0048255	mRNA stabilization
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:2000623	negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0010494	cytoplasmic stress granule
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0036464	cytoplasmic ribonucleoprotein granule
GO:0071013	catalytic step 2 spliceosome

Protein Structure and Domains

PDB ID

InterPro

IPR000504 RNA recognition motif domain
IPR002004 Polyadenylate-binding protein/Hyperplastic disc protein
IPR003954 RNA recognition motif domain, eukaryote
IPR006515 Polyadenylate binding protein, human types 1, 2, 3, 4

PFAM

PF00076
PF00658

PRINTS

PIRSF

SMART

SM00360
SM00517
SM00361

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P11940