Homo sapiens Protein: MYL3
Summary
InnateDB Protein IDBP-30907.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYL3
Protein Name myosin, light chain 3, alkali; ventricular, skeletal, slow
Synonyms CMH8; MLC1SB; MLC1V; VLC1;
Species Homo sapiens
Ensembl Protein ENSP00000292327
InnateDB Gene IDBG-30905 (MYL3)
Protein Structure
UniProt Annotation
Function Regulatory light chain of myosin. Does not bind calcium.
Subcellular Localization
Disease Associations Cardiomyopathy, familial hypertrophic 8 (CMH8) [MIM:608751]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Rarely, patients present a variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening. {ECO:0000269PubMed:12021217, ECO:0000269PubMed:12707239, ECO:0000269PubMed:8673105}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003785 actin monomer binding
GO:0005509 calcium ion binding
GO:0008307 structural constituent of muscle
GO:0032038 myosin II heavy chain binding
Biological Process
GO:0002026 regulation of the force of heart contraction
GO:0006942 regulation of striated muscle contraction
GO:0030049 muscle filament sliding
GO:0032781 positive regulation of ATPase activity
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060048 cardiac muscle contraction
Cellular Component
GO:0005829 cytosol
GO:0005859 muscle myosin complex
GO:0030017 sarcomere
GO:0031672 A band
GO:0031674 I band
Protein Structure and Domains
PDB ID
InterPro IPR002048 EF-hand domain
PFAM PF00036
PF13202
PF13405
PRINTS
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P08590
PhosphoSite PhosphoSite-P08590
TrEMBL Q14909
UniProt Splice Variant
Entrez Gene 4634
UniGene Hs.713332
RefSeq NP_000249
HUGO HGNC:7584
OMIM 160790
CCDS CCDS2746
HPRD 01183
IMGT
EMBL AC109583 AF174483 AK312044 BC009790 CH471055 M24122 M24242 M24243 M24244 M24245 M24246 M24247 M76408 X07373
GenPept AAA59851 AAA59894 AAA59895 AAF91089 AAH09790 BAG34981 CAA30292 EAW64791 EAW64792