InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLCO3A1

Summary

InnateDB Protein

IDBP-30913.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLCO3A1

Protein Name

solute carrier organic anion transporter family, member 3A1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000320634

InnateDB Gene

IDBG-30911 (SLCO3A1)

Protein Structure

UniProt Annotation

Function

Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595). Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3- sulfate, taurocholate, digoxin nor DHEAS (PubMed:16971491). {ECO:0000269PubMed:10873595, ECO:0000269PubMed:16971491}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Ubiquitous. Highly expressed in spleen and leukocytes. Generally the expression of isoform 1 is higher than that of isoform 2. Isoform 2 is particularly abundant in testis and brain. In testis, isoform 1 is detected in spermatogonia at different stages and absent from Sertoli cells, while isoform 2 is present in both (at protein level). Expressed in the choroid plexus epithelium, isoform 1 being localized at the basolateral membrane and isoform 2 at the apical one, as well as in the subapical intracellular vesicular compartments. Differential expression of both isoforms is also observed in other brain region: isoform 1 is very abundant in the gray matter of the frontal cortex, but is not associated with neuronal cell bodies. Not detected in the white matter. In contrast, isoform 2 is associated with neuronal bodies and axons in both the gray and the white matters of the frontal cortex. {ECO:0000269PubMed:16971491}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0043252	sodium-independent organic anion transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002350 Kazal domain
IPR004156 Organic anion transporter polypeptide OATP
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter

PFAM

PF00050
PF07648
PF03137
PF07690

PRINTS

PIRSF

SMART

SM00280

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UIG8