InnateDB Protein
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IDBP-30942.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AKIP1
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Protein Name
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A kinase (PRKA) interacting protein 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000299576
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InnateDB Gene
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IDBG-30938 (AKIP1)
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Protein Structure
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Function |
Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. {ECO:0000269PubMed:18178962, ECO:0000269PubMed:20562110}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:15630084, ECO:0000269PubMed:18178962}. Note=Locates to punctate spots.
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Disease Associations |
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Tissue Specificity |
Expressed at high levels in adult heart and at lower levels in brain, testis, ovary and skeletal muscle. Up- regulated in some breast cancer cell lines. Isoform 1 and isoform 3 are expressed in fetal brain. {ECO:0000269PubMed:12527432, ECO:0000269PubMed:15630084}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NQ31
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PhosphoSite |
PhosphoSite-Q9NQ31
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
56672
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UniGene |
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RefSeq |
NP_001193575
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HUGO |
HGNC:1170
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OMIM |
609191
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CCDS |
CCDS55744
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HPRD |
12380
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IMGT |
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EMBL |
AF493783
AF493784
AF493785
AF493786
AF512007
AJ400877
AK075308
BC030996
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GenPept |
AAH30996
AAM12862
AAM12863
AAM12864
AAM12865
AAM12866
AAM12867
AAM34785
BAC11537
CAB92290
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