InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RHEBL1

Summary

InnateDB Protein

IDBP-30984.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RHEBL1

Protein Name

Ras homolog enriched in brain like 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000301068

InnateDB Gene

IDBG-30982 (RHEBL1)

Protein Structure

UniProt Annotation

Function

Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2. {ECO:0000269PubMed:12869548, ECO:0000269PubMed:16098514, ECO:0000269PubMed:16328882, ECO:0000269PubMed:17162089}.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:16328882}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Expression increased at least 2-fold in several tumor cell lines. {ECO:0000269PubMed:16006564, ECO:0000269PubMed:16328882}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0031929	TOR signaling
GO:0051092	positive regulation of NF-kappaB transcription factor activity

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00071
PF00025
PF08477

PRINTS

PR00315
PR00449
PR00328

PIRSF

SMART

SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt