Version 5.4
Homo sapiens Protein: SMC6
Summary
InnateDB Protein IDBP-31224.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMC6
Protein Name structural maintenance of chromosomes 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000370672
InnateDB Gene IDBG-31220 (SMC6)
Protein Structure
UniProt Annotation
Function Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. {ECO:0000269PubMed:16810316, ECO:0000269PubMed:17589526}.
Subcellular Localization Nucleus. Chromosome. Chromosome, telomere. Note=Associates with chromatin. Localizes to PML nuclear bodies in ALT cell lines.
Disease Associations
Tissue Specificity Widely expressed. Overexpressed in testis. {ECO:0000269PubMed:11408570}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0000722 telomere maintenance via recombination
GO:0000724 double-strand break repair via homologous recombination
GO:0090398 cellular senescence
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0016605 PML body
GO:0030915 Smc5-Smc6 complex
Protein Structure and Domains
PDB ID
InterPro IPR003395 RecF/RecN/SMC, N-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF02463
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96SB8
PhosphoSite PhosphoSite-Q96SB8
TrEMBL C9JEF0
UniProt Splice Variant
Entrez Gene 79677
UniGene Hs.733296
RefSeq
HUGO HGNC:20466
OMIM 609387
CCDS
HPRD 10242
IMGT
EMBL AC093731 AC097377 AJ310551 AK025769 AK292421 AL136544 AL832979 BC032675 BC039828 CH471053
GenPept AAH32675 AAH39828 AAX88851 BAB15236 BAF85110 CAB66479 CAC39248 CAH56327 EAX00866 EAX00867 EAX00868

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca