InnateDB Protein
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IDBP-31638.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ADM
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Protein Name
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adrenomedullin
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Synonyms
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AM; PAMP;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000278175
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InnateDB Gene
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IDBG-31636 (ADM)
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Protein Structure
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Function |
AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001710
Adrenomedullin
IPR021116
Procalcitonin/adrenomedullin
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PFAM |
PF00214
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PRINTS |
PR00801
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P35318
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PhosphoSite |
PhosphoSite-P35318
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TrEMBL |
E9PL83
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UniProt Splice Variant |
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Entrez Gene |
133
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UniGene |
Hs.441047
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RefSeq |
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HUGO |
HGNC:259
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OMIM |
103275
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CCDS |
CCDS7801
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HPRD |
00061
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IMGT |
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EMBL |
AC080023
AK312893
BC015961
BT006902
CH471064
CR541995
D14874
D43639
DQ143945
S73906
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GenPept |
AAC60642
AAH15961
AAP35548
AAZ38717
BAA03589
BAA07756
BAG35740
CAG46792
EAW68571
EAW68572
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