Version 5.4
Homo sapiens Protein: FMNL3
Summary
InnateDB Protein IDBP-31840.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FMNL3
Protein Name formin-like 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000344311
InnateDB Gene IDBG-31836 (FMNL3)
Protein Structure
UniProt Annotation
Function Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. {ECO:0000269PubMed:21834987}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:21834987}. Note=Enriched in lamellipodia.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005488 binding
GO:0017048 Rho GTPase binding
GO:0032794 GTPase activating protein binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0008360 regulation of cell shape
GO:0016043 cellular component organization
GO:0016477 cell migration
GO:0030036 actin cytoskeleton organization
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR010472 Formin, FH3 domain
IPR010473 Formin, GTPase-binding domain
IPR015425 Formin, FH2 domain
IPR016024 Armadillo-type fold
PFAM PF06367
PF06371
PF02181
PRINTS
PIRSF
SMART SM00498
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IVF7
PhosphoSite PhosphoSite-Q8IVF7
TrEMBL
UniProt Splice Variant
Entrez Gene 91010
UniGene Hs.708422
RefSeq NP_944489
HUGO HGNC:23698
OMIM
CCDS CCDS41780
HPRD 17007
IMGT
EMBL AB095934 AC020612 AK128195 BC159100
GenPept AAI59101 BAC23110 BAC87319

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca