InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NCOR1

Summary

InnateDB Protein

IDBP-31973.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCOR1

Protein Name

nuclear receptor corepressor 1

Synonyms

hN-CoR; N-CoR; N-CoR1; PPP1R109; TRAC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000268712

InnateDB Gene

IDBG-31971 (NCOR1)

Protein Structure

UniProt Annotation

Function

Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. {ECO:0000269PubMed:14527417}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00624}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 236 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	236 [view]
Protein-Protein	223 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0035033	histone deacetylase regulator activity
GO:0035257	nuclear hormone receptor binding
GO:0042826	histone deacetylase binding
GO:0042974	retinoic acid receptor binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046965	retinoid X receptor binding
GO:0046966	thyroid hormone receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002361	CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007219	Notch signaling pathway
GO:0010467	gene expression
GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling
GO:0016568	chromatin modification
GO:0021794	thalamus development
GO:0031065	positive regulation of histone deacetylation
GO:0032922	circadian regulation of gene expression
GO:0040014	regulation of multicellular organism growth
GO:0042632	cholesterol homeostasis
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046329	negative regulation of JNK cascade
GO:0051225	spindle assembly
GO:0060318	definitive erythrocyte differentiation
GO:0072362	regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter
GO:0072368	regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
GO:2000191	regulation of fatty acid transport

Cellular Component

GO:0000118	histone deacetylase complex
GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005876	spindle microtubule
GO:0016020	membrane
GO:0016580	Sin3 complex
GO:0017053	transcriptional repressor complex