Homo sapiens Protein: NCOR1
InnateDB Protein IDBP-31973.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCOR1
Protein Name nuclear receptor corepressor 1
Synonyms hN-CoR; N-CoR; N-CoR1; PPP1R109; TRAC1;
Species Homo sapiens
Ensembl Protein ENSP00000268712
InnateDB Gene IDBG-31971 (NCOR1)
Protein Structure
UniProt Annotation
Function Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. {ECO:0000269PubMed:14527417}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00624}.
Disease Associations
Tissue Specificity
Number of Interactions This gene and/or its encoded proteins are associated with 236 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 236 [view]
Protein-Protein 223 [view]
Protein-DNA 10 [view]
Protein-RNA 0
DNA-DNA 3 [view]
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0035033 histone deacetylase regulator activity
GO:0035257 nuclear hormone receptor binding
GO:0042826 histone deacetylase binding
GO:0042974 retinoic acid receptor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046965 retinoid X receptor binding
GO:0046966 thyroid hormone receptor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0010467 gene expression
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
GO:0016568 chromatin modification
GO:0021794 thalamus development
GO:0031065 positive regulation of histone deacetylation
GO:0032922 circadian regulation of gene expression
GO:0040014 regulation of multicellular organism growth
GO:0042632 cholesterol homeostasis
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046329 negative regulation of JNK cascade
GO:0051225 spindle assembly
GO:0060318 definitive erythrocyte differentiation
GO:0072362 regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter
GO:0072368 regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
GO:2000191 regulation of fatty acid transport
Cellular Component
GO:0000118 histone deacetylase complex
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005876 spindle microtubule
GO:0016020 membrane
GO:0016580 Sin3 complex
GO:0017053 transcriptional repressor complex
Protein Structure and Domains
InterPro IPR001005 SANT/Myb domain
IPR009057 Homeodomain-like
IPR017877 Myb-like domain
PFAM PF00249
Post-translational Modifications
SwissProt O75376
PhosphoSite PhosphoSite-O75376
UniProt Splice Variant
Entrez Gene 9611
UniGene Hs.666008
RefSeq NP_006302
OMIM 600849
HPRD 02911
EMBL AB019524 AB028970 AC002553 AC005971 AF044209 AF303586 AK295893 AL137641 BC167431 CH471222
GenPept AAC33550 AAI67431 AAO32942 BAA75814 BAA82999 BAG58687 CAB70854 EAX04492 EAX04493 EAX04494