InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CENPV

Summary

InnateDB Protein

IDBP-32144.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CENPV

Protein Name

centromere protein V

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000299736

InnateDB Gene

IDBG-32142 (CENPV)

Protein Structure

UniProt Annotation

Function

Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis. {ECO:0000269PubMed:18772885}.

Subcellular Localization

Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Enriched at the nuclear periphery and around the nucleolus. In mitotic cells, localizes to kinetochores from prometaphase to metaphase. At anaphase onset, transfers to the spindle midzone and then to the mid-body in telophase and cytokinesis.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0016846	carbon-sulfur lyase activity

Biological Process

GO:0001667	ameboidal cell migration
GO:0007067	mitotic nuclear division
GO:0008152	metabolic process
GO:0031508	centromeric heterochromatin assembly
GO:0032467	positive regulation of cytokinesis
GO:0033044	regulation of chromosome organization
GO:0034508	centromere complex assembly

Cellular Component

GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0015630	microtubule cytoskeleton
GO:0051233	spindle midzone