InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MT1E

Summary

InnateDB Protein

IDBP-32185.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MT1E

Protein Name

metallothionein 1E

Synonyms

MT1; MTD;

Species

Homo sapiens

Ensembl Protein

ENSP00000307706

InnateDB Gene

IDBG-32183 (MT1E)

Protein Structure

UniProt Annotation

Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0045926	negative regulation of growth
GO:0071276	cellular response to cadmium ion
GO:0071294	cellular response to zinc ion

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000006 Metallothionein, vertebrate
IPR003019 Metallothionein superfamily, eukaryotic
IPR017854 Metallothionein domain

PFAM

PF00131

PRINTS

PR00860

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P04732

PhosphoSite

PhosphoSite-P04732

TrEMBL

UniProt Splice Variant

Entrez Gene

4493

UniGene

RefSeq

NP_783316

HUGO

HGNC:7397

OMIM

156351

CCDS

CCDS10764

HPRD

01126

IMGT

EMBL

AC026461 AF348996 AF495759 BC009699 BC062734 BC131609 CH471092 M10942 S68949

GenPept

AAA59587 AAB30082 AAH09699 AAH62734 AAI31610 AAM15968 AAO32956 EAW82872 EAW82874