InnateDB Protein
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IDBP-32309.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MRI1
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Protein Name
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methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000040663
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InnateDB Gene
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IDBG-32307 (MRI1)
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Protein Structure
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Function |
Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover. {ECO:0000255HAMAP-Rule:MF_03119, ECO:0000269PubMed:19620624}.
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Subcellular Localization |
Nucleus {ECO:0000255HAMAP-Rule:MF_03119, ECO:0000269PubMed:19620624}. Cytoplasm {ECO:0000255HAMAP- Rule:MF_03119, ECO:0000269PubMed:19620624}. Cell projection {ECO:0000269PubMed:19620624}. Note=Primarily nuclear, but cytoplasmic in cancer cells, with enrichment at leading edge of the plasma membrane in late stage tumor cells.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0042802
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identical protein binding
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GO:0046523
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S-methyl-5-thioribose-1-phosphate isomerase activity
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Biological Process |
GO:0000096
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sulfur amino acid metabolic process
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GO:0006595
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polyamine metabolic process
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GO:0019284
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L-methionine biosynthetic process from S-adenosylmethionine
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GO:0019509
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L-methionine biosynthetic process from methylthioadenosine
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GO:0034641
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cellular nitrogen compound metabolic process
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GO:0044237
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cellular metabolic process
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GO:0044249
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cellular biosynthetic process
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GO:0044281
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small molecule metabolic process
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Cellular Component |
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PDB ID |
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InterPro |
IPR000649
Initiation factor 2B-related
IPR005251
Methylthioribose-1-phosphate isomerase
IPR011559
Initiation factor 2B alpha/beta/delta
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PFAM |
PF01008
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BV20
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PhosphoSite |
PhosphoSite-Q9BV20
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
84245
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UniGene |
Hs.712891
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RefSeq |
NP_001026897
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HUGO |
HGNC:28469
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OMIM |
615105
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CCDS |
CCDS32923
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HPRD |
14548
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IMGT |
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EMBL |
AL834276
AY358176
BC001703
CH471106
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GenPept |
AAH01703
AAQ88543
CAD38951
EAW84370
EAW84371
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