InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NANOS3

Summary

InnateDB Protein

IDBP-32401.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NANOS3

Protein Name

nanos homolog 3 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000341992

InnateDB Gene

IDBG-32399 (NANOS3)

Protein Structure

UniProt Annotation

Function

Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax- dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis. {ECO:0000269PubMed:21421998}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:21421998}. Cytoplasm {ECO:0000269PubMed:21421998}. Cytoplasmic granule {ECO:0000250}. Cytoplasm, P-body {ECO:0000250}. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with PUM2, EIF2S1 and TIAL1 in the stress granules. Colocalizes with DCP1A in the P-body (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Ovary, testis and brain (at protein level). In the ovaries, expressed during multiple stages of oogenesis, including primordial, primary, secondary and antral follicles with the highest expression in the oocytes. In the testis, expressed in germ cells, type A spermatogonia (SA), primary spermatocytes (S1), round spermatids (S3) and elongated spermatids. {ECO:0000269PubMed:21421998}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0006417	regulation of translation
GO:0007275	multicellular organismal development
GO:0007281	germ cell development
GO:0007283	spermatogenesis
GO:0048477	oogenesis
GO:0051726	regulation of cell cycle
GO:2001234	negative regulation of apoptotic signaling pathway

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0010494	cytoplasmic stress granule
GO:0048471	perinuclear region of cytoplasm