InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYO5B

Summary

InnateDB Protein

IDBP-3290.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYO5B

Protein Name

myosin VB

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000285039

InnateDB Gene

IDBG-3288 (MYO5B)

Protein Structure

UniProt Annotation

Function

May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Diarrhea 2, with microvillus atrophy (DIAR2) [MIM:251850]: A disease characterized by onset of intractable life-threatening watery diarrhea during infancy. Two forms are recognized: early-onset microvillus inclusion disease with diarrhea beginning in the neonatal period, and late-onset, with first symptoms appearing after 3 or 4 months of life. {ECO:0000269PubMed:18724368}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0017137	Rab GTPase binding

Biological Process

GO:0006833	water transport
GO:0008152	metabolic process
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0055085	transmembrane transport

Cellular Component

GO:0016459	myosin complex
GO:0030659	cytoplasmic vesicle membrane
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR001609 Myosin head, motor domain
IPR002710 Dilute
IPR009053 Prefoldin
IPR018444 Dil domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF00063
PF01843

PRINTS

PR00193

PIRSF

SMART

SM00015
SM00242

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt