InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCL17

Summary

InnateDB Protein

IDBP-33238.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCL17

Protein Name

chemokine (C-C motif) ligand 17

Synonyms

A-152E5.3; ABCD-2; SCYA17; TARC;

Species

Homo sapiens

Ensembl Protein

ENSP00000219244

InnateDB Gene

IDBG-33236 (CCL17)

Protein Structure

UniProt Annotation

Function

Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4. {ECO:0000269PubMed:10540332}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed at high levels in thymus and at low levels in the lung, colon and small intestine.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	6 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0008009	chemokine activity
GO:0031729	CCR4 chemokine receptor binding

Biological Process

GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0045087	innate immune response (InnateDB)
GO:0060326	cell chemotaxis