Homo sapiens Protein: PAPSS1 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-33298.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | PAPSS1 | ||||||||||||||||||
Protein Name | 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | ||||||||||||||||||
Synonyms | ATPSK1; PAPSS; SK1; | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000265174 | ||||||||||||||||||
InnateDB Gene | IDBG-33296 (PAPSS1) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells. | ||||||||||||||||||
Subcellular Localization | |||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Expressed in testis, pancreas, kidney, thymus, prostate, ovary, small intestine, colon, leukocytes and liver. Also expressed in high endothelial venules (HEV) cells and in cartilage. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR002650
Sulphate adenylyltransferase IPR002891 Adenylylsulphate kinase IPR015947 PUA-like domain IPR024951 Sulphate adenylyltransferase catalytic domain IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF01583
PF01747 |
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PRINTS | |||||||||||||||||||
PIRSF | |||||||||||||||||||
SMART | |||||||||||||||||||
TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | O43252 | ||||||||||||||||||
PhosphoSite | PhosphoSite-O43252 | ||||||||||||||||||
TrEMBL | Q6IAX6 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 9061 | ||||||||||||||||||
UniGene | Hs.712578 | ||||||||||||||||||
RefSeq | NP_005434 | ||||||||||||||||||
HUGO | HGNC:8603 | ||||||||||||||||||
OMIM | 603262 | ||||||||||||||||||
CCDS | CCDS3676 | ||||||||||||||||||
HPRD | 09132 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC098586 AC106861 AF016496 AF033026 AF097710 AF097711 AF097712 AF097713 AF097714 AF097715 AF097716 AF097717 AF097718 AF097719 AF097720 AF097721 AF105227 AK292774 BC011392 BC050627 CH471057 CR457028 U53447 Y10387 | ||||||||||||||||||
GenPept | AAC28429 AAC39894 AAD09325 AAF40235 AAF40236 AAH11392 AAH50627 AAY40925 AAY41043 BAF85463 CAA71413 CAG33309 EAX06210 | ||||||||||||||||||