InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CALCB

Summary

InnateDB Protein

IDBP-33413.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CALCB

Protein Name

calcitonin-related polypeptide beta

Synonyms

CALC2; CGRP-II; CGRP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000346017

InnateDB Gene

IDBG-33411 (CALCB)

Protein Structure

UniProt Annotation

Function

CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0005184	neuropeptide hormone activity

Biological Process

GO:0006874	cellular calcium ion homeostasis
GO:0007165	signal transduction

Cellular Component

GO:0005576

extracellular region

Protein Structure and Domains

PDB ID

InterPro

IPR000443 Pro-islet amyloid polypeptide
IPR001693 Calcitonin peptide-like
IPR015476 Calcitonin gene-related peptide
IPR021116 Procalcitonin/adrenomedullin

PFAM

PF00214

PRINTS

PR00818
PR00817

PIRSF

SMART

SM00113

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt