InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DRG2

Summary

InnateDB Protein

IDBP-33503.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DRG2

Protein Name

developmentally regulated GTP binding protein 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000225729

InnateDB Gene

IDBG-33501 (DRG2)

Protein Structure

UniProt Annotation

Function

May play a role in cell proliferation, differentiation and death.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Highest levels in skeletal muscle, heart and kidney. Low levels in colon, thymus, spleen, small intestine, lung and Leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005525	GTP binding
GO:0015093	ferrous iron transmembrane transporter activity

Biological Process

GO:0007165	signal transduction
GO:0015684	ferrous iron transport

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR004095 TGS
IPR005225 Small GTP-binding protein domain
IPR006073 GTP binding domain
IPR011619 Ferrous iron transport protein B, N-terminal
IPR012676 TGS-like
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF02824
PF01926
PF02421

PRINTS

PR00326

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P55039