InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RHOBTB3

Summary

InnateDB Protein

IDBP-33976.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RHOBTB3

Protein Name

Rho-related BTB domain containing 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000369318

InnateDB Gene

IDBG-33974 (RHOBTB3)

Protein Structure

UniProt Annotation

Function

Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9. {ECO:0000269PubMed:19490898}.

Subcellular Localization

Golgi apparatus {ECO:0000269PubMed:19490898}.

Disease Associations

Tissue Specificity

Ubiquitous. Highly expressed in neural and cardiac tissues, pancreas, placenta and testis. {ECO:0000269PubMed:12426103}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0016887	ATPase activity
GO:0017137	Rab GTPase binding

Biological Process

GO:0006200	ATP catabolic process
GO:0007264	small GTPase mediated signal transduction
GO:0042147	retrograde transport, endosome to Golgi

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus

Protein Structure and Domains

PDB ID

InterPro

IPR000210 BTB/POZ-like
IPR001806 Small GTPase superfamily
IPR011333 BTB/POZ fold
IPR013069 BTB/POZ
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF00651

PRINTS

PR00449

PIRSF

SMART

SM00225

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt