Homo sapiens Protein: LRRC17 | |||||
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Summary | |||||
InnateDB Protein | IDBP-34064.6 | ||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||
Gene Symbol | LRRC17 | ||||
Protein Name | leucine rich repeat containing 17 | ||||
Synonyms | P37NB; | ||||
Species | Homo sapiens | ||||
Ensembl Protein | ENSP00000249377 | ||||
InnateDB Gene | IDBG-34060 (LRRC17) | ||||
Protein Structure | |||||
UniProt Annotation | |||||
Function | Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors (By similarity). {ECO:0000250}. | ||||
Subcellular Localization | Secreted, extracellular space {ECO:0000250}. | ||||
Disease Associations | |||||
Tissue Specificity | Expressed in osteoblast cell lines. Well expressed in ovary, heart, pancreas, skeletal muscle, lung, and fetal kidney and lung and only at the basal levels in the other tissues examined including adult kidney. More expressed in S-type neuroblastoma cells than in N-type neuroblastoma cells. {ECO:0000269PubMed:19336404, ECO:0000269PubMed:8982252}. | ||||
Comments | |||||
Interactions | |||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||
PDB ID | |||||
InterPro |
IPR001611
Leucine-rich repeat IPR003591 Leucine-rich repeat, typical subtype |
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PFAM |
PF00560
PF13504 PF13855 |
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PRINTS | |||||
PIRSF | |||||
SMART |
SM00369
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TIGRFAMs | |||||
Post-translational Modifications | |||||
Modification | |||||
Cross-References | |||||
SwissProt | Q8N6Y2 | ||||
PhosphoSite | PhosphoSite-Q8N6Y2 | ||||
TrEMBL | C9JT74 | ||||
UniProt Splice Variant | |||||
Entrez Gene | 10234 | ||||
UniGene | Hs.567412 | ||||
RefSeq | NP_005815 | ||||
HUGO | HGNC:16895 | ||||
OMIM | |||||
CCDS | CCDS5727 | ||||
HPRD | 10059 | ||||
IMGT | |||||
EMBL | AC005250 AC073127 AY358889 BC027903 U32907 | ||||
GenPept | AAB41565 AAH27903 AAQ89248 AAS07483 | ||||