Version 5.4
Homo sapiens Protein: WIZ
Summary
InnateDB Protein IDBP-34652.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WIZ
Protein Name widely interspaced zinc finger motifs
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000373933
InnateDB Gene IDBG-34648 (WIZ)
Protein Structure
UniProt Annotation
Function May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 44 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0010571 positive regulation of nuclear cell cycle DNA replication
GO:0050821 protein stabilization
GO:0070208 protein heterotrimerization
Cellular Component
GO:0005634 nucleus
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95785
PhosphoSite PhosphoSite-O95785
TrEMBL B9EGQ5
UniProt Splice Variant
Entrez Gene 58525
UniGene Hs.733695
RefSeq XP_005260063
HUGO HGNC:30917
OMIM
CCDS
HPRD
IMGT
EMBL AC006128 AC007059 AC011492 AK027615 AK131404 AL390184 BC002329 BC007551 BC062360 BC098445 BC136641 BC144332
GenPept AAC97985 AAD19817 AAD19818 AAH02329 AAH07551 AAH62360 AAH98445 AAI36642 AAI44333 BAB55234 BAD18551 CAB99102

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca