Version 5.4
Homo sapiens Protein: KRT71
Summary
InnateDB Protein IDBP-34728.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT71
Protein Name keratin 71
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000267119
InnateDB Gene IDBG-34726 (KRT71)
Protein Structure
UniProt Annotation
Function Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). {ECO:0000305}.
Subcellular Localization
Disease Associations
Tissue Specificity Highly expressed in hair follicles from scalp. Specifically expressed in the inner root sheath (IRS) of the hair follicle. Present in the all 3 IRS layers: the cuticle, the Henle and the Huxley layers. Also detected in the pseudopods of specialized Huxley cells, termed Fluegelzellen, along the area of differentiated Henle cells (at protein level). {ECO:0000269PubMed:11982755, ECO:0000269PubMed:12648212, ECO:0000269PubMed:16874310}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
Biological Process
GO:0031069 hair follicle morphogenesis
Cellular Component
GO:0005882 intermediate filament
GO:0045095 keratin filament
Protein Structure and Domains
PDB ID
InterPro IPR001664 Intermediate filament protein
IPR003054 Keratin, type II
IPR009053 Prefoldin
PFAM PF00038
PRINTS PR01276
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3SY84
PhosphoSite PhosphoSite-Q3SY84
TrEMBL
UniProt Splice Variant
Entrez Gene 112802
UniGene Hs.660007
RefSeq NP_258259
HUGO HGNC:28927
OMIM 608245
CCDS CCDS8831
HPRD 09745
IMGT
EMBL AC055736 AJ308599 AK122795 BC103917 BC103918 CH471054
GenPept AAI03918 AAI03919 BAG53733 CAC43429 EAW96636

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca