Version 5.4
Homo sapiens Protein: ELAC1
Summary
InnateDB Protein IDBP-3478.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ELAC1
Protein Name elaC homolog 1 (E. coli)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000269466
InnateDB Gene IDBG-3476 (ELAC1)
Protein Structure
UniProt Annotation
Function Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
Subcellular Localization Cytoplasm, cytosol {ECO:0000269PubMed:21593607}. Nucleus {ECO:0000269PubMed:21593607}. Note=Mainly cytosolic.
Disease Associations
Tissue Specificity Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269PubMed:11401430}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters
GO:0046872 metal ion binding
Biological Process
GO:0042779 tRNA 3'-trailer cleavage
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR001279 Beta-lactamase-like
IPR013471 Ribonuclease Z/BN
PFAM PF00753
PRINTS
PIRSF
SMART SM00849
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H777
PhosphoSite PhosphoSite-Q9H777
TrEMBL
UniProt Splice Variant
Entrez Gene 55520
UniGene Hs.657360
RefSeq NP_061166
HUGO HGNC:14197
OMIM 608079
CCDS CCDS11949
HPRD 16275
IMGT
EMBL AB029151 AF308695 AK024822 BC014624
GenPept AAG24917 AAH14624 BAA96799 BAB15021

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca