InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDH11

Summary

InnateDB Protein

IDBP-34797.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDH11

Protein Name

cadherin 11, type 2, OB-cadherin (osteoblast)

Synonyms

CAD11; CDHOB; OB; OSF-4;

Species

Homo sapiens

Ensembl Protein

ENSP00000268603

InnateDB Gene

IDBG-34793 (CDH11)

Protein Structure

UniProt Annotation

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.

Disease Associations

Note=A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.

Tissue Specificity

Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding

Biological Process

GO:0001501	skeletal system development
GO:0001503	ossification
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion
GO:0021957	corticospinal tract morphogenesis
GO:0034329	cell junction assembly
GO:0034332	adherens junction organization
GO:0045216	cell-cell junction organization