InnateDB Protein
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IDBP-35379.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MRGPRX1
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Protein Name
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MAS-related GPR, member X1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000305766
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InnateDB Gene
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IDBG-35377 (MRGPRX1)
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Protein Structure
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Function |
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine- induced itch, in a histamine-independent manner. {ECO:0000269PubMed:11850634, ECO:0000269PubMed:20004959}.
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Subcellular Localization |
Cell membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons. {ECO:0000269PubMed:11850634}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0004930
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G-protein coupled receptor activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like
IPR017452
GPCR, rhodopsin-like, 7TM
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PFAM |
PF00001
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PRINTS |
PR00237
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96LB2
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PhosphoSite |
PhosphoSite-Q96LB2
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TrEMBL |
W8W3P5
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UniProt Splice Variant |
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Entrez Gene |
259249
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UniGene |
Hs.711459
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RefSeq |
NP_671732
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HUGO |
HGNC:17962
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OMIM |
607227
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CCDS |
CCDS7846
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HPRD |
06246
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IMGT |
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EMBL |
AB065846
AB083628
AC023078
AF474989
AF474990
AY042213
BC096835
CH471064
HG426070
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GenPept |
AAH96835
AAK91804
AAL86880
AAL86881
BAB89341
BAC06064
CDG86188
EAW68360
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