InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CKAP2

Summary

InnateDB Protein

IDBP-35505.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CKAP2

Protein Name

cytoskeleton associated protein 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000367276

InnateDB Gene

IDBG-35503 (CKAP2)

Protein Structure

UniProt Annotation

Function

Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules in G1, S and early G2. At late G2 and prophase after separation of duplicated centrosomes, colocalizes with gamma-tubulin and centrosome- proximal microtubules. From prometaphase through anaphase B, colocalizes with mitotic spindle poles and spindle microtubules. During cytokinesis, absent from midbody microtubules.

Disease Associations

Tissue Specificity

Abundant in testis, thymus, and in tumor derived cell lines, while barely detectable in liver, prostate, and kidney. {ECO:0000269PubMed:9771967}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0000281	mitotic cytokinesis
GO:0006915	apoptotic process
GO:0007026	negative regulation of microtubule depolymerization
GO:0045944	positive regulation of transcription from RNA polymerase II promoter