Version 5.4
Homo sapiens Protein: CKAP2
Summary
InnateDB Protein IDBP-35507.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CKAP2
Protein Name cytoskeleton associated protein 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000258607
InnateDB Gene IDBG-35503 (CKAP2)
Protein Structure
UniProt Annotation
Function Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules in G1, S and early G2. At late G2 and prophase after separation of duplicated centrosomes, colocalizes with gamma-tubulin and centrosome- proximal microtubules. From prometaphase through anaphase B, colocalizes with mitotic spindle poles and spindle microtubules. During cytokinesis, absent from midbody microtubules.
Disease Associations
Tissue Specificity Abundant in testis, thymus, and in tumor derived cell lines, while barely detectable in liver, prostate, and kidney. {ECO:0000269PubMed:9771967}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0000281 mitotic cytokinesis
GO:0006915 apoptotic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0000922 spindle pole
GO:0005813 centrosome
GO:0005881 cytoplasmic microtubule
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WWK9
PhosphoSite PhosphoSite-Q8WWK9
TrEMBL E9PD90
UniProt Splice Variant
Entrez Gene 26586
UniGene Hs.444028
RefSeq NP_060674
HUGO HGNC:1990
OMIM 611569
CCDS CCDS9435
HPRD 10832
IMGT
EMBL AF177227 AJ429398 AK001611 AK022982 AL136848 AL359513 AY062261 AY062262 BC010901 BC105806 BC130296 EF560732 Y15758
GenPept AAG33675 AAH10901 AAI05807 AAI30297 AAL47212 AAL47213 ABQ59042 BAA91788 BAB14345 CAB66782 CAC17466 CAD22295 CAH71660 CAH71661

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca