InnateDB Protein
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IDBP-35509.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CKAP2
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Protein Name
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cytoskeleton associated protein 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000367273
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InnateDB Gene
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IDBG-35503 (CKAP2)
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Protein Structure
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Function |
Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules in G1, S and early G2. At late G2 and prophase after separation of duplicated centrosomes, colocalizes with gamma-tubulin and centrosome- proximal microtubules. From prometaphase through anaphase B, colocalizes with mitotic spindle poles and spindle microtubules. During cytokinesis, absent from midbody microtubules.
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Disease Associations |
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Tissue Specificity |
Abundant in testis, thymus, and in tumor derived cell lines, while barely detectable in liver, prostate, and kidney. {ECO:0000269PubMed:9771967}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8WWK9
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PhosphoSite |
PhosphoSite-Q8WWK9
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TrEMBL |
C9J649
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UniProt Splice Variant |
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Entrez Gene |
26586
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UniGene |
Hs.444028
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RefSeq |
NP_001273616
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HUGO |
HGNC:1990
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OMIM |
611569
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CCDS |
CCDS73578
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HPRD |
10832
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IMGT |
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EMBL |
AF177227
AJ429398
AK001611
AK022982
AL136848
AL359513
AY062261
AY062262
BC010901
BC105806
BC130296
EF560732
Y15758
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GenPept |
AAG33675
AAH10901
AAI05807
AAI30297
AAL47212
AAL47213
ABQ59042
BAA91788
BAB14345
CAB66782
CAC17466
CAD22295
CAH71660
CAH71661
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