InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CSRP3

Summary

InnateDB Protein

IDBP-35521.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSRP3

Protein Name

cysteine and glycine-rich protein 3 (cardiac LIM protein)

Synonyms

CLP; CMD1M; CMH12; CRP3; LMO4; MLP;

Species

Homo sapiens

Ensembl Protein

ENSP00000265968

InnateDB Gene

IDBG-35519 (CSRP3)

Protein Structure

UniProt Annotation

Function

Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}. Cytoplasm {ECO:0000269PubMed:18505755}. Cytoplasm, cytoskeleton {ECO:0000305}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Mainly cytoplasmic (By similarity). In the nucleus it associates with the actin cytoskeleton (Potential). In the Z line, found associated with GLRX3 (By similarity). {ECO:0000250, ECO:0000305}.

Disease Associations

Cardiomyopathy, dilated 1M (CMD1M) [MIM:607482]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. {ECO:0000269PubMed:12507422}. Note=The disease is caused by mutations affecting the gene represented in this entry.Cardiomyopathy, familial hypertrophic 12 (CMH12) [MIM:612124]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. {ECO:0000269PubMed:12642359, ECO:0000269PubMed:18505755}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Cardiac and slow-twitch skeletal muscles.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0008307	structural constituent of muscle
GO:0031433	telethonin binding
GO:0042805	actinin binding

Biological Process

GO:0002026	regulation of the force of heart contraction
GO:0003300	cardiac muscle hypertrophy
GO:0006874	cellular calcium ion homeostasis
GO:0007519	skeletal muscle tissue development
GO:0033365	protein localization to organelle
GO:0035995	detection of muscle stretch
GO:0048738	cardiac muscle tissue development
GO:0055003	cardiac myofibril assembly
GO:0060048	cardiac muscle contraction