InnateDB Protein
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IDBP-35628.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NAV2
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Protein Name
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neuron navigator 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000353871
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InnateDB Gene
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IDBG-35624 (NAV2)
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Protein Structure
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Function |
Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269PubMed:12214280, ECO:0000269PubMed:15158073}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:12214280}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in the brain, kidney and liver. Also expressed in the thyroid, mammary gland, spinal cord, heart, placenta and lung. Abundantly expressed in colon cancers. {ECO:0000269PubMed:11904404, ECO:0000269PubMed:12062803, ECO:0000269PubMed:12079279, ECO:0000269PubMed:12214280}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001715
Calponin homology domain
IPR003593
AAA+ ATPase domain
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00307
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PRINTS |
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PIRSF |
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SMART |
SM00033
SM00382
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TIGRFAMs |
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Modification |
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SwissProt |
Q8IVL1
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PhosphoSite |
PhosphoSite-Q8IVL1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
89797
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UniGene |
Hs.623782
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RefSeq |
NP_001104488
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HUGO |
HGNC:15997
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OMIM |
607026
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CCDS |
CCDS53612
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HPRD |
07385
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IMGT |
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EMBL |
AB037840
AB063115
AB063116
AC009549
AC015684
AC023950
AC090662
AC111163
AC113193
AF466143
AF466144
AJ488102
AJ488203
AJ488204
AJ488205
AJ488206
AJ488207
AJ488208
AK001495
AK001892
AK074287
BC016054
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GenPept |
AAH16054
AAL96479
AAL96480
BAA91723
BAA91965
BAA92657
BAB85038
BAC00853
BAC00854
CAD32471
CAD32556
CAD32557
CAD32558
CAD32559
CAD32560
CAD32561
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