Version 5.4
Homo sapiens Protein: WRB
Summary
InnateDB Protein IDBP-3563.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WRB
Protein Name tryptophan rich basic protein
Synonyms CHD5;
Species Homo sapiens
Ensembl Protein ENSP00000370084
InnateDB Gene IDBG-3557 (WRB)
Protein Structure
UniProt Annotation
Function Receptor for ASNA1/TRC40-mediated insertion of tail- anchored (TA) proteins into the ER membrane. {ECO:0000269PubMed:21444755}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:21444755, ECO:0000269PubMed:9544840}; Multi- pass membrane protein {ECO:0000269PubMed:21444755, ECO:0000269PubMed:9544840}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0071816 tail-anchored membrane protein insertion into ER membrane
Cellular Component
GO:0005634 nucleus
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR028945 WRB/Get1 family
PFAM PF04420
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O00258
PhosphoSite PhosphoSite-O00258
TrEMBL Q0VGA7
UniProt Splice Variant
Entrez Gene 7485
UniGene Hs.741308
RefSeq NP_001139690
HUGO HGNC:12790
OMIM 602915
CCDS CCDS54485
HPRD 04224
IMGT
EMBL AF064861 AF121781 AK293113 AK299144 AL163279 BC012415 BC111393 CH471079 Y12478
GenPept AAH12415 AAI11394 BAF85802 BAG61196 CAA73081 CAB90454 EAX09645 EAX09647 EAX09649

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca