InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MST1R

Summary

InnateDB Protein

IDBP-35724.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MST1R

Protein Name

macrophage stimulating 1 receptor (c-met-related tyrosine kinase)

Synonyms

CD136; CDw136; PTK8; RON;

Species

Homo sapiens

Ensembl Protein

ENSP00000341325

InnateDB Gene

IDBG-35720 (MST1R)

Protein Structure

UniProt Annotation

Function

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand. {ECO:0000269PubMed:18836480, ECO:0000269PubMed:7939629, ECO:0000269PubMed:9764835}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed in colon, skin, lung and bone marrow. {ECO:0000269PubMed:8062829}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	28 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004872	receptor activity
GO:0005011	macrophage colony-stimulating factor receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019899	enzyme binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006928	cellular component movement
GO:0006952	defense response
GO:0007165	signal transduction
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275	multicellular organismal development
GO:0007338	single fertilization
GO:0008284	positive regulation of cell proliferation
GO:0009615	response to virus
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0038145	macrophage colony-stimulating factor signaling pathway
GO:0043406	positive regulation of MAP kinase activity
GO:0045087	innate immune response (InnateDB)
GO:0051897	positive regulation of protein kinase B signaling

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001627 Sema domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR002909 IPT domain
IPR011009 Protein kinase-like domain
IPR014756 Immunoglobulin E-set
IPR016201 Plexin-like fold
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF01403
PF01833

PRINTS

PR00109

PIRSF

SMART

SM00630
SM00220
SM00429
SM00423
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt