InnateDB Protein
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IDBP-36062.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PCDH8
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Protein Name
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protocadherin 8
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Synonyms
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ARCADLIN; PAPC;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000367177
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InnateDB Gene
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IDBG-36060 (PCDH8)
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Protein Structure
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Function |
Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane. Note=Also expressed in neuronal cell bodies. Localized to excitatory, but not with inhibitory, synapses. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002126
Cadherin
IPR013164
Cadherin, N-terminal
IPR015919
Cadherin-like
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PFAM |
PF00028
PF08266
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PRINTS |
PR00205
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PIRSF |
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SMART |
SM00112
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TIGRFAMs |
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Modification |
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SwissProt |
O95206
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PhosphoSite |
PhosphoSite-O95206
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
5100
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UniGene |
Hs.19492
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RefSeq |
NP_002581
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HUGO |
HGNC:8660
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OMIM |
603580
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CCDS |
CCDS9438
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HPRD |
04660
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IMGT |
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EMBL |
AF061573
AK297652
AL139085
AY013873
BC036025
CH471124
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GenPept |
AAC70009
AAH36025
AAK21986
BAG60019
CAI14110
CAI14111
EAW52049
EAW52050
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