Version 5.4
Homo sapiens Protein: MSRA
Summary
InnateDB Protein IDBP-360870.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MSRA
Protein Name methionine sulfoxide reductase A
Synonyms PMSR;
Species Homo sapiens
Ensembl Protein ENSP00000410912
InnateDB Gene IDBG-7004 (MSRA)
Protein Structure
UniProt Annotation
Function Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
Subcellular Localization Isoform 1: Mitochondrion.Isoform 2: Cytoplasm.Isoform 3: Cytoplasm. Nucleus.Isoform 5: Cytoplasm. Membrane; Lipid- anchor.
Disease Associations
Tissue Specificity Ubiquitous. Highest expression in adult kidney and cerebellum, followed by liver, heart ventricles, bone marrow and hippocampus.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008113 peptide-methionine (S)-S-oxide reductase activity
Biological Process
GO:0006464 cellular protein modification process
GO:0006555 methionine metabolic process
GO:0006979 response to oxidative stress
GO:0030091 protein repair
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002569 Peptide methionine sulphoxide reductase MsrA
PFAM PF01625
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UJ68
PhosphoSite PhosphoSite-Q9UJ68
TrEMBL
UniProt Splice Variant
Entrez Gene 4482
UniGene
RefSeq NP_001129142
HUGO HGNC:7377
OMIM 601250
CCDS CCDS47798
HPRD 03152
IMGT
EMBL AC023385 AC034111 AC079200 AC112673 AF086925 AF183420 AJ242973 AK293488 AY690665 AY958429 AY958430 AY958431 AY958432 BC054033 CH471157
GenPept AAG09689 AAH54033 AAP97154 AAU11088 AAY17426 AAY17427 AAY17428 AAY17429 AAY17430 AAY17431 BAH11521 CAB59628 EAW65584 EAW65585

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca