InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WHSC2

Summary

InnateDB Protein

IDBP-360924.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WHSC2

Protein Name

Wolf-Hirschhorn syndrome candidate 2

Synonyms

NELF-A; WHSC2;

Species

Homo sapiens

Ensembl Protein

ENSP00000399165

InnateDB Gene

IDBG-7253 (WHSC2)

Protein Structure

UniProt Annotation

Function

Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Probably required to interact with the RNA polymerase II complex. {ECO:0000269PubMed:10199401, ECO:0000269PubMed:12563561, ECO:0000269PubMed:12612062}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11150502}.

Disease Associations

Tissue Specificity

Ubiquitous. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. Expressed at lower level in adult lung. Expressed in fetal brain, lung, liver and kidney. {ECO:0000269PubMed:10409432, ECO:0000269PubMed:11150502, ECO:0000269PubMed:12612062}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003746	translation elongation factor activity
GO:0005515	protein binding

Biological Process

GO:0006366	transcription from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0006414	translational elongation
GO:0007275	multicellular organismal development
GO:0010467	gene expression
GO:0016032	viral process
GO:0050434	positive regulation of viral transcription