InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APP

Summary

InnateDB Protein

IDBP-361147.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APP

Protein Name

amyloid beta (A4) precursor protein

Synonyms

AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2;

Species

Homo sapiens

Ensembl Protein

ENSP00000398879

InnateDB Gene

IDBG-1100 (APP)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2628 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	2628 [view]
Protein-Protein	2625 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0008201	heparin binding
GO:0046914	transition metal ion binding

Biological Process

GO:0007399	nervous system development
GO:0010951	negative regulation of endopeptidase activity

Cellular Component

GO:0005794	Golgi apparatus
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR002223 Proteinase inhibitor I2, Kunitz metazoa
IPR008154 Amyloidogenic glycoprotein, extracellular
IPR008155 Amyloidogenic glycoprotein
IPR011178 Amyloidogenic glycoprotein, copper-binding
IPR013803 Amyloidogenic glycoprotein, amyloid-beta peptide
IPR015849 Amyloidogenic glycoprotein, heparin-binding
IPR019543 Beta-amyloid precursor protein C-terminal
IPR024329 Amyloidogenic glycoprotein, E2 domain

PFAM

PF00014
PF12924
PF03494
PF02177
PF10515
PF12925

PRINTS

PR00759
PR00203
PR00204

PIRSF

SMART

SM00131
SM00006

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt