InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IGF2

Summary

InnateDB Protein

IDBP-361738.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IGF2

Protein Name

insulin-like growth factor 2 (somatomedin A)

Synonyms

C11orf43; IGF-II; PP9974;

Species

Homo sapiens

Ensembl Protein

ENSP00000414497

InnateDB Gene

IDBG-20829 (IGF2)

Protein Structure

UniProt Annotation

Function

The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.

Subcellular Localization

Secreted.

Disease Associations

Silver-Russell syndrome (SRS) [MIM:180860]: A clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations. The phenotypic expression changes during childhood and adolescence, with the facial features and asymmetry usually becoming more subtle with age. {ECO:0000269PubMed:19066168}. Note=The gene represented in this entry is involved in disease pathogenesis. Most of the cases of Silver-Russell syndrome are caused by the epigenetic changes of DNA hypomethylation at the telomeric imprinting control region (ICR1) on chromosome 11p15, involving the H19 and IGF2 genes.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	20 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005158	insulin receptor binding
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0030546	receptor activator activity
GO:0043539	protein serine/threonine kinase activator activity

Biological Process

GO:0001501	skeletal system development
GO:0001934	positive regulation of protein phosphorylation
GO:0002576	platelet degranulation
GO:0006006	glucose metabolic process
GO:0006349	regulation of gene expression by genetic imprinting
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0007596	blood coagulation
GO:0008284	positive regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0030168	platelet activation
GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0042104	positive regulation of activated T cell proliferation
GO:0043085	positive regulation of catalytic activity
GO:0043410	positive regulation of MAPK cascade
GO:0044267	cellular protein metabolic process
GO:0045725	positive regulation of glycogen biosynthetic process
GO:0045840	positive regulation of mitosis
GO:0046628	positive regulation of insulin receptor signaling pathway
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051781	positive regulation of cell division
GO:0051897	positive regulation of protein kinase B signaling
GO:2000467	positive regulation of glycogen (starch) synthase activity

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0031093	platelet alpha granule lumen
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR013576 Insulin-like growth factor II E-peptide, C-terminal
IPR016179 Insulin-like
IPR022334 Insulin-like growth factor II
IPR022350 Insulin-like growth factor
IPR022352 Insulin family

PFAM

PF08365
PF00049

PRINTS

PR02006
PR02002
PR00276

PIRSF

SMART

SM00078

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt