InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IGF2

Summary

InnateDB Protein

IDBP-361749.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IGF2

Protein Name

insulin-like growth factor 2 (somatomedin A)

Synonyms

C11orf43; IGF-II; PP9974;

Species

Homo sapiens

Ensembl Protein

ENSP00000391826

InnateDB Gene

IDBG-20829 (IGF2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	20 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005158	insulin receptor binding
GO:0005159	insulin-like growth factor receptor binding
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0030546	receptor activator activity
GO:0043539	protein serine/threonine kinase activator activity

Biological Process

GO:0001501	skeletal system development
GO:0001649	osteoblast differentiation
GO:0001934	positive regulation of protein phosphorylation
GO:0002576	platelet degranulation
GO:0006006	glucose metabolic process
GO:0006349	regulation of gene expression by genetic imprinting
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0007565	female pregnancy
GO:0007596	blood coagulation
GO:0007613	memory
GO:0008284	positive regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0009314	response to radiation
GO:0009887	organ morphogenesis
GO:0014070	response to organic cyclic compound
GO:0030168	platelet activation
GO:0031017	exocrine pancreas development
GO:0031667	response to nutrient levels
GO:0032355	response to estradiol
GO:0035094	response to nicotine
GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0042060	wound healing
GO:0042104	positive regulation of activated T cell proliferation
GO:0042493	response to drug
GO:0043085	positive regulation of catalytic activity
GO:0043410	positive regulation of MAPK cascade
GO:0044267	cellular protein metabolic process
GO:0045471	response to ethanol
GO:0045725	positive regulation of glycogen biosynthetic process
GO:0045840	positive regulation of mitosis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046628	positive regulation of insulin receptor signaling pathway
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051146	striated muscle cell differentiation
GO:0051781	positive regulation of cell division
GO:0051897	positive regulation of protein kinase B signaling
GO:0071260	cellular response to mechanical stimulus
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:0090031	positive regulation of steroid hormone biosynthetic process
GO:2000273	positive regulation of receptor activity
GO:2000467	positive regulation of glycogen (starch) synthase activity

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0031093	platelet alpha granule lumen
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR013576 Insulin-like growth factor II E-peptide, C-terminal
IPR016179 Insulin-like
IPR022334 Insulin-like growth factor II
IPR022350 Insulin-like growth factor
IPR022352 Insulin family

PFAM

PF08365
PF00049

PRINTS

PR02006
PR02002
PR00276

PIRSF

SMART

SM00078

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt