InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TULP3

Summary

InnateDB Protein

IDBP-362079.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TULP3

Protein Name

tubby like protein 3

Synonyms

TUBL3;

Species

Homo sapiens

Ensembl Protein

ENSP00000410051

InnateDB Gene

IDBG-12543 (TULP3)

Protein Structure

UniProt Annotation

Function

Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein- coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis. {ECO:0000269PubMed:11375483, ECO:0000269PubMed:20889716}.

Subcellular Localization

Nucleus. Cell membrane. Cell projection, cilium. Cytoplasm {ECO:0000250}. Secreted {ECO:0000250}. Note=Does not have a cleavable signal peptide and is secreted by a non- conventional pathway (By similarity). Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide- binding protein G(q) subunit alpha. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at high levels in testis, ovaries, thyroid, and spinal chord. {ECO:0000269PubMed:9828123}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	3 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0019899	enzyme binding
GO:0032403	protein complex binding
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007275	multicellular organismal development
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0045879	negative regulation of smoothened signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005929	cilium
GO:0030991	intraciliary transport particle A
GO:0072372	primary cilium
GO:0097546	ciliary base