InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRAPPC2

Summary

InnateDB Protein

IDBP-362177.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRAPPC2

Protein Name

trafficking protein particle complex 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000392495

InnateDB Gene

IDBG-44932 (TRAPPC2)

Protein Structure

UniProt Annotation

Function

Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic reticulum to Golgi. {ECO:0000250}.

Subcellular Localization

Cytoplasm, perinuclear region. Endoplasmic reticulum. Golgi apparatus. Nucleus. Note=Localized in perinuclear granular structures.

Disease Associations

Spondyloepiphyseal dysplasia tarda (SEDT) [MIM:313400]: X-linked recessive disorder of endochondral bone formation. {ECO:0000269PubMed:10431248, ECO:0000269PubMed:11349230, ECO:0000269PubMed:11424925}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, fetal cartilage, fibroblasts, placenta and lymphocytes. {ECO:0000269PubMed:10431248}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0044325	ion channel binding

Biological Process

GO:0001501	skeletal system development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006810	transport
GO:0006888	ER to Golgi vesicle-mediated transport

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005801	cis-Golgi network
GO:0048471	perinuclear region of cytoplasm