InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: E2F4

Summary

InnateDB Protein

IDBP-36223.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

E2F4

Protein Name

E2F transcription factor 4, p107/p130-binding

Synonyms

E2F-4;

Species

Homo sapiens

Ensembl Protein

ENSP00000368686

InnateDB Gene

IDBG-36221 (E2F4)

Protein Structure

UniProt Annotation

Function

Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Found in all tissue examined including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 483 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	485 [view]
Protein-Protein	77 [view]
Protein-DNA	405 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019904	protein domain specific binding

Biological Process

GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0002064	epithelial cell development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006884	cell volume homeostasis
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0008015	blood circulation
GO:0008361	regulation of cell size
GO:0009887	organ morphogenesis
GO:0010467	gene expression
GO:0042127	regulation of cell proliferation
GO:0042384	cilium assembly
GO:0045944	positive regulation of transcription from RNA polymerase II promoter