InnateDB Protein
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IDBP-36268.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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EXOSC9
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Protein Name
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exosome component 9
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Synonyms
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p5; p6; PM/Scl-75; PMSCL1; RRP45; Rrp45p;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000368984
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InnateDB Gene
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IDBG-36262 (EXOSC9)
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Protein Structure
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Function |
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs. {ECO:0000269PubMed:11782436, ECO:0000269PubMed:16455498, ECO:0000269PubMed:16912217, ECO:0000269PubMed:17545563}.
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Subcellular Localization |
Cytoplasm. Nucleus, nucleolus.Isoform 1: Nucleus, nucleolus.Isoform 2: Nucleus, nucleolus.Isoform 3: Nucleus. Note=Excluded from the nucleolus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
34
[view]
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Protein-Protein |
31
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0000288
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nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
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GO:0000956
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nuclear-transcribed mRNA catabolic process
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GO:0006364
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rRNA processing
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GO:0006955
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immune response
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GO:0010467
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gene expression
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GO:0016070
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RNA metabolic process
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GO:0016071
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mRNA metabolic process
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GO:0030307
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positive regulation of cell growth
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GO:0043928
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exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
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GO:0071028
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nuclear mRNA surveillance
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GO:0071035
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nuclear polyadenylation-dependent rRNA catabolic process
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GO:0090503
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RNA phosphodiester bond hydrolysis, exonucleolytic
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Cellular Component |
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PDB ID |
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InterPro |
IPR001247
Exoribonuclease, phosphorolytic domain 1
IPR015847
Exoribonuclease, phosphorolytic domain 2
IPR020568
Ribosomal protein S5 domain 2-type fold
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PFAM |
PF01138
PF03725
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q06265
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PhosphoSite |
PhosphoSite-Q06265
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
5393
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UniGene |
Hs.91728
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RefSeq |
NP_001029366
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HUGO |
HGNC:9137
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OMIM |
606180
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CCDS |
CCDS34057
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HPRD |
07315
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IMGT |
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EMBL |
AC079341
AJ505989
AJ517294
M58460
U09215
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GenPept |
AAA18832
AAA58384
AAY40968
CAD44530
CAD56889
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