InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IPO4

Summary

InnateDB Protein

IDBP-3629.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IPO4

Protein Name

importin 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000346453

InnateDB Gene

IDBG-3627 (IPO4)

Protein Structure

UniProt Annotation

Function

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. {ECO:0000250, ECO:0000269PubMed:11823430}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.

Experimentally validated
Total	44 [view]
Protein-Protein	44 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008536	Ran GTPase binding

Biological Process

GO:0006335	DNA replication-dependent nucleosome assembly
GO:0006336	DNA replication-independent nucleosome assembly
GO:0006886	intracellular protein transport
GO:0015031	protein transport